Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality

Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality

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Abstract Introduction Exsanguination due to uncontrolled bleeding is the leading cause of potentially preventable deaths among trauma patients.About one third of trauma patients present with coagulopathy on admission, which is associated with increased mortality and will aggravate bleeding in a traumatized patient.Thrombelastographic (TEG) clot strength has previously been here shown to predict outcome in critically ill patients.

The aim of the present study was to investigate this relation in the trauma setting.Methods A retrospective study of trauma patients with an injury severity qualifying them for inclusion in the European Trauma Audit and Research Network (TARN) and a TEG analysis performed upon arrival at the trauma centre.Results Eighty-nine patients were included.

The mean Injury Severity Score (ISS) was 21 with a 30-day mortality of 17%.Patients with a reduced clot strength (maximal amplitude Conclusion Low clot strength upon admission is independently associated with increased tonic shower cap 30-day mortality in trauma patients and it could be speculated that targeted interventions based on the result of the TEG analysis may improve patient outcome.Prospective randomized trials investigating this potential are highly warranted.